Biochemical markers of lipoprotein metabolism: standard lipid panel, apoB, and Lp(a).
Dyslipoproteinemias: causes and laboratory diagnostics
Laboratory markers for evaluation of glycemia control.
Biochemical markers of myocardial injury: sensitivity, specificity and clinical interpretation
Diabetes mellitus laboratory diagnostics
Universal definition of myocardial infarction and role of biochemical markers
Biochemical markers of heart failure: sensitivity, specificity and clinical utility
Cholestasis syndrome. Pathogenesis and laboratory diagnosis.
Cytolysis syndrome. Pathogenesis and laboratory diagnosis.
Clinical importance of alkaline phosphatase (ALP), amino transferases (AST, ALT), glutamyl transferase (GGT) tests.
Biomarkers of bilirubin metabolism in blood and urine and their clinical interpretation.
CRP, alpha1-antitrypsin, procalcitonin, ceruloplasmin proteins, their functions, clinical significance.
Microalbuminuria, risk factors, reference ranges, diagnostics.
Dysproteinemias. Hypoproteinemia and hyperproteinemia causes
Definition and indications for protein electrophoresis.
The main non-protein nitrogenous substances. Causes of uremia and hyperuricemia.
Clinical significance of tumor markers. Classification of tumor markers.
Carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), prostate specific antigen (PSA), their functions and clinical significance.
Laboratory tests for differentiation of acquired bleeding disorders due to trauma, hepatic pathology, vitamin K deficiency and renal insufficiency
Laboratory monitoring of acquired bleeding disorders
Laboratory diagnosis and monitoring of von Willebrand disease (VWD)
Laboratory diagnosis of single clotting factor deficiencies (FVIII, FIX and FXI) and monitoring of factor/non-factor replacement therapies.
Screening lab tests that are used for diagnosis/monitoring of bleeding disorders.
Importance of AT, p and S, APC-R, FV Leiden, Prothrombin G20210A and Lupus anticoagulants tests in assessment of risk for the venous thromboembolism.
Interpretation of D-dimer test.
Microbiological culture: principle and workflow of the testing procedure. Causes of lack of sensitivity of microbiological culture.
Microorganism antigens that can be detected in biological samples.
Diagnosis of infection by antibody testing in blood serum
Compare methods used in microbiology in terms of sensitivity & specificity.
Principles of antimicrobial therapy
Methods for determining antibiotic susceptibility.
Horizontal spread of resistance genes and its mechanism
Human pathogenic streptococci
Laboratory diagnostic markers (autoantibodies) of rheumatic diseases & their interpretation
Laboratory diagnostic markers of autoimmune vasculitis and their interpretation
Laboratory diagnostic markers of autoimmune kidney diseases & their interpretation
Laboratory assessment of humoral immunity
Assessment of T-cell immunity
Evaluation of the function of phagocytic cells (neutrophils)
RBC, Hct, Hgb parameters and their interpretation in a CBC test.
MCV and RDW parameters and their interpretation in a CBC test.
Reticulocyte parameters and their interpretation in a CBC test.
NRBC parameter and its interpretation in a CBC test.
Definition of pseudothrombocytopenia & its possible causes.
Changes in laboratory parameters characteristic to Iron deficiency anemia (IDA).
Changes in laboratory parameters characteristic to megaloblastic anemia.
Changes in laboratory parameters characteristic to chronic myeloid leukemia.
Changes in laboratory parameters characteristic to chronic lymphocytic leukemia.
Clinical interpretation of glucosuria, ketonuria, proteinuria, bilirubinuria, urobilinogen in urine,leukocyturia, bacteriuria, and hematuria.
Indications for urine sediment examination. Elements in urine sediment examination. Clinicalsignificance of epithelial cells in urine.
Polymerase chain reaction (PCR): principle & interpretation of results.
Basic principles of primer designing & its tools.
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