Describe the primary therapy of brain metastases.
Limited brain metastases: surgical resection or stereotactic radiosurgery (e.g., Gamma Knife, CyberKnife, proton beam)
Extensive brain metastases: stereotactic radiosurgery, whole-brain radiation therapy, or chemotherapy
What are addiotional therapeutic options?
Glucocorticoids to reduce tumor edema
Patients with a high primary tumor burden and a poor functional status (Karnofsky score) can be treated palliatively.
Describe the prognosis with and without treatment.
Without treatment: mean survival ∼ 1 month
With treatment: mean survival < 1 year