WOUND HEALING

Phases of Wound Healing

Phases of wound healing: precedes inflammation with the ensuing release of chemotactic factors from the wound site

Are the first infiltrating cells to enter the wound site, peaking agg 24-48 hours

PMNs are the major source of cytokines early during inflammation, especially TNF-a, which may have a significant influence on subsequent ___

Second population of inflammatory cells that invades the wound, which are essential to successful wound healing. They achieve significant numbers in the wound by 48-96 hours post-injury and remain present until wound healing is complete

Peak about 1 week post injury and truly bridge the transition from the inflammatory to the proliferative phase of healing

Proliferative phase is th second phaseof wound healing and roughly spans what days?

phases of wound healing: it is during this phase that tissue continue continuity is reestablished.

Last cell populations to infiltrate the healing woud

Strongest chemotactic factor for fibroblast

Primary function of fibroblast

Accumulates in significant amounts in the wound environment overtime, is a potent regulator of collagen synthesis through a mechanism involving ADP- ribosylation

Also proliferate extensively during maturation and remodeling phase. These cells participte in the formation of new capillaries

Represent a major source of VEGF in the healing wound

Collagen types for wound repair

Major glycosaminoglycans present in wounds

Maturation and remodeling phase of he scar begins during fibroplastic change and is characterized by

Collagen is broken down by

Characteristic pattern of the deposition of matrix at the wound site

Glycoprotein secreted by fibroblasts is essential for the formation of elastic fibers found in connective tissue

Final step in establishing tissue integrity

Epithelialization begins within 1 day of injury and is seen as