Stem cell exhaustion

What are stem cells?

Asymmetrical division

Properties fo adult stem cells

Stem cells and Aging

Intrinsic drivers of stem cells aging

(Mitochondrial dyfunction & ROS)

(Loss of proteostasis)

Summary: Molecular damage in aging stem cells

DNA damage in stem cells

Telomeres in aged stem cells

Epigenetic alteration in stem cells

Summary pathways in stem cell exhaustion

Extrinsic mechanisms

Stem cell niche

Aging of the stem cell niche

(Heterochronic parabiosis experiments)

External factors contributing to stem cell aging

General features of stem cell aging