Define peritoneal carcinomatosis.
a terminal feature of abdominal cancers (most commonly of the ovary, appendix, or colon) characterized by seeding of the tumor to the peritoneum
Describe the epidemiology.
depends on underlying malignancy; peritoneal carcinomatosis develops in ∼ 10% of individuals with colorectal cancer
Which diagnostic test is preferred?
CT is preferred; typically shows metastatic studding (tumor nodules studding the surface of the peritoneum) and omental caking
Describe the treatment.
Operable disease: involves cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC), systemic chemotherapy, targeted therapy, and/or immune checkpoint inhibitors
Inoperable disease: experimental pressurized intraperitoneal aerosolized chemotherapy or repeated intraperitoneal chemotherapy infusion
What are complications and what is the prognosis?
Complications: bowel, biliary, and/or ureteral obstruction
Prognosis: poor; 5-year survival rates after CRS and HIPEC are approx. 40%