Define chronic lymphocytic leukemia.
a type of proliferative B-cell malignancy that manifests with lymphocytic leukocytosis
Define lymphocytic lymphoma (SLL).
a type of B-cell lymphoma with the same genetic and molecular markers as CLL that manifests primarily in the lymph nodes, bone marrow, and other lymphatic tissue rather than with leukocytosis
How common is CLL?
Most common type of leukemia in adults
Sex: ♂ > ♀ (∼ 2:1)
Age: The median age at the time of diagnosis is 70–72 years (incidence of CLL increases with age).
Describe the pathophysiology.
Acquired mutations in hematopoietic stem cells → increased proliferation of leukemic B cells with impaired maturation and differentiation in the bone marrow, resulting in:
Suppression of the proliferation of normal blood cells
Infiltration of the lymph nodes, liver, and spleen