List clinical features of the chronic phase.
Can persist for up to 10 years and is often subclinical
When symptomatic, features include:
Weight loss, fever, night sweats, fatigue
Splenomegaly: abdominal discomfort in the left upper quadrant
Lymphadenopathy is not typical in CML.
List clinical features of the accelerated phase.
Neutropenia: infection and fever
Infarctions: splenic and myocardial infarctions, retinal vessel occlusion
Terminal phase: myelofibrosis
Extreme splenomegaly : palpable in lower left quadrant or pelvic cavity
List clinical features of the blast crisis.
The blast crisis is the terminal stage of CML.
Symptoms resemble those of acute leukemia.
Rapid progression of bone marrow failure → pancytopenia, bone pain
Myeloid blast crisis → AML (⅔ of cases)
Lymphoid blast crisis → ALL (⅓ of cases)