Treatment

• All individuals with HIV infection, regardless of CD4 count, should begin antiretroviral therapy (ART) as soon as possible

  • Antiretroviral drugs are combined to prevent resistance.

  • All antiretroviral drugs are able to target both HIV-1 and HIV-2, except for enfuvirtide and NNRTIs.

• Tailor therapy to the HIV genotype, if needed.

• Establish regular monitoring to assess treatment response.

• If CD4 count is < 200, start prophylaxis for opportunistic infections.

• 2 NRTIs PLUS 1 NNRTI

• 2 NRTIs PLUS 1 PI (boosted)

• 2 NRTIs PLUS 1 INI

• 1 NRTI PLUS 1 INI

NRTI = Nucleoside reverse transcriptase inhibitors

NNRTI = Nonnucleoside reverse transcriptase inhibitors

INI = Integrase inhibitors