Name the category.
Cytotoxic agents.
Name the main drug.
Cisplatin
Describe the mechanism of action.
Cross-links between DNA strands → ↓ DNA replication
List indications.
Lymphomas
Solid tumors
Bladder cancer (cisplatin)
Testicular cancer (cisplatin)
Ovarian cancer (cisplatin, carboplatin)
Colorectal cancer (oxaliplatin)
Lung cancer (cisplatin, carboplatin)
Cervical cancer (cisplatin)
Osteosarcoma (cisplatin)
List side effects.
Myelosuppression
Nephrotoxicity (may manifest as Fanconi syndrome)
Neurotoxicity (including peripheral neuropathies)
Ototoxicity
CINV
Last changed2 years ago