Name the category.
Immunomodulator agents.
Name the main drug.
Azathioprine
What is the subgroup?
Purine analog
Describe the mechanism of action.
Purine analog (antimetabolite precursor of 6-mercaptopurine ) → ↓ nucleotide synthesis → ↓ proliferation of lymphocytes
Cytostatic effect at a high dosage via inhibition of cell proliferation
Immunosuppressive effect at a low dosage with significant inhibition of lymphocyte proliferation
Is there a Suppression of cell-mediated immune response and Suppression of humoral immune response?
Cell mediated: Yes
Humoral: (Yes)
List indications.
Transplant rejection prophylaxis
To suppress various inflammatory and autoimmune reactions
Atopy and asthma
Adrenal insufficiency
Part of the regimen for the treatment of:
CLL
Non-Hodgkin lymphoma
What are the adverse effects?
See side effects glucocorticoid therapy
Last changed2 years ago