Name the category.
GI Agents
List 2 main drugs.
Aluminium hydroxide
Sucralfate
What are indications for antacids (aluminium hydroxide)?
Gastroesophageal reflux disease
Symptomatic treatment of peptic ulcers
Describe the mechanism of action of aluminum hydroxide.
Alkalinization of gastric acid via alkaline ions
Name adverse effects of antacids, especially aluminum hydroxide.
Hypokalemia
Constipation
Hypophosphatemia
Osteodystrophy
What is sucralfate?
a sucrose sulfate-aluminum complex that reacts with HCl in an acidic environment to create a protective barrier over the gastric/duodenal mucosa
Describe the mechanism of action of sucralfate.
Acts as an acid buffer and promotes HCO3 production
Should not be taken simultaneously with a PPI or H2 blocker
Last changed2 years ago