Name the category.
Genitourinary Agents
List 2 main drugs.
Doxazosin
Tamsulosin
Which drug class do doxazosin and tamsulosin belong to?
Alpha-1 receptor antagonists
Describe the indications for doxazosin.
Benign prostatic hyperplasia
Arterial hypertension
Name the indication for tamsulosin.
List adverse effects.
Orthostatic hypotension
Retrograde ejaculation
Dizziness, headache
Peripheral edema, hypotension
Nausea, constipation
Intraoperative floppy iris syndrome (IFIS)
Complication of cataract surgery characterized by iris prolapse through the surgical incision and intraoperative pupillary constriction
May lead to retinal detachment and endophthalmitis
Urinary frequency
Prazosin: priapism
Describe the general mechanism of action of alpha-1 receptor antagonists.
Inhibit alpha-1 receptors (e.g., in smooth muscle)
List the main effects of alpha-1 receptor antagonists.
↓ Vasoconstriction → ↓ blood pressure
Relaxation of bladder neck muscles → ↓ bladder outlet obstruction and easier micturition
In alpha blockers capable of crossing the blood-brain barrier (prazosin): ↓ alpha-1-mediated CNS stress response → ↓ nightmares secondary to PTSD
List general indications for alpha-1 receptor antagonists.
Hypertension
Symptoms control in benign prostatic hyperplasia
PTSD-related nightmares
Last changed2 years ago