Name the categogy.
Antidementia Agents
Name the main drug.
Memantine
List the indications.
Moderate to severe AD
Often used in combination with donepezil
Describe the mechanism of action.
NMDA receptor antagonism → ↓ glutamate-induced calcium-mediated excitotoxicity
Memantine binds to NMDA receptors, acting as a noncompetitive antagonist and thus blocking the activity of glutamate.
List adverse events.
Headaches
Dizziness
Confusion
Hallucinations
Seizures
Constipation
Last changed2 years ago