Name the category.
Immunomodulators
Name the main drug.
Anti-D (Rho) Immunoglobulin
Describe the background of Anti-D immunoglobulin (RhoGAM)
An antibody against the rhesus D antigen. Commonly used as prophylaxis against hemolytic disease of the fetus and newborn in Rh(D) negative mothers. Also used in the treatment of immune thrombocytopenia (ITP)
Anti-D prophylaxis protects newborns in subsequent pregnancies.
Only indicated in unsensitized mothers
Anti-D prophylaxis has no benefit for the fetus of sensitized mothers.
Describe the indication and implementation of Anti-D IG
Anti-D prophylaxis should be administered during the 28th week of gestation and within 72 hours following the birth of an Rh-positive baby.
Anti-D prophylaxis is not necessary if the father is confirmed as Rh negative.
The efficacy of anti-D prophylaxis relies on antibody-mediated immunosuppression.
Anti-D immunoglobulins lead to the elimination of fetal RhD erythrocytes as soon as they enter the maternal circulation and prior to the production of antibodies by the maternal immune system.
List further indications in Rh negativity for Anti-D IG.
Following a miscarriage, ectopic pregnancy, or termination of pregnancy
Bleeding during pregnancy
Following invasive procedures (e.g., amniocentesis, chorionic villus sampling)
Describe the dosage of Anti-D IG.
Standard dose: 300 μg (1500 IU) IV/IM
If whole fetal blood is > 30 mL (i.e., fetal RBCs > 15 mL): 300 μg (1500 IU) IM should be given for every 30 mL of fetal blood volume.
Last changed2 years ago