Name the category.
Lipid-regulating drugs.
Name the main drug
Ezetimibe
Describe the mechanism of action.
selective inhibition of cholesterol reabsorption at the brush border of enterocytes (cholesterol transporter NPC1L1) → ↓↓ LDL, little effect on HDL (slight ↑) and triglycerides (slight ↓)
List indications.
Monotherapy: in contraindications or statin intolerance
Combination therapy (statin and ezetimibe): in insufficient LDL cholesterol reduction by statins
List adverse effects.
rare, except in combination therapy
↑ Liver enzymes
Angioedema
Diarrhea
Myalgia
Name one contraindication.
coadministration with a statin during active liver disease
Last changed2 years ago