Name the main drug.
Nystatin
Describe the routes of administration.
(too toxic for intravenous use)
Topical
Vaginal candidiasis
Diaper rash
Oral (swish and swallow): oropharyngeal candidiasis
List adverse effects.
Gastrointestinal symptoms (e.g., diarrhea, nausea, pain)
Contact dermatitis
Stevens-Johnson syndrome
What is 1 contraindication?
pregnancy
Describe the indication.
Used mainly for the treatment of systemic fungal infections
Considered a subgroup of macrolide antibiotics
For oropharyngeal candidiasis, the medication should be swished around in the mouth, gargled, and then swallowed (swish and swallow).
Describe the mechanism of action (of polyenes, the overarching drug group).
bind to ergosterol in the fungal cell membrane → formation of pores in the fungal membrane → disruption of electrolyte balance → cell lysis → cell death
Last changed2 years ago