Name the category.
Antiparasistics
Name the 2 drugs.
Quinine
Chloroquine
List indications.
Treatment and prophylaxis of malaria due to P. malariae, P. ovale, or P. vivax
Falciparum malaria
Chloroquine resistant P. vivax infection
Chloroquine resistant P. ovale infection
P. malariea infection
P. knowlesi infection
Describe the mechanism of action.
Drug accumulation in the parasite's food vacuole → inhibition of heme polymerization → lysis of membranes
Interference with antigen processing → antirheumatic effects
List the most common adverse effects of chlorquine.
Gastrointestinal discomfort
Nausea with cramps (most common)
Irreversible bilateral retinopathy (bull's eye maculopathy)
Pruritus: most commonly seen in dark-skinned individuals [34]
CNS: agitation, anxiety, confusion
List the most common adverse effects of quinine
Cinchonism: a group of adverse effects including nausea, dizziness, headache, tinnitus, and visual changes.
Hypoglycemia
Fever, flushing
CNS: headache, mental status altered
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