Name the category.
Antivirals
Name 3 main drugs.
Efavirenz
Tenofovir
Darunavir
Name an alternative drug.
Cabotegravir
What is the overarching drug group of the listed drugs?
Nonnucleoside reverse-transcriptase inhibitors (NNRTIs)
Describe the mechanism of action.
Noncompetitive inhibitors of viral reverse transcriptase that bind to the reverse transcriptase at a different location than NRTIs
NNRTIs do not require intracellular phosphorylation for activation because they are direct inhibitors.
List general adverse effects.
Hypersensitivity reactions: rash
Stevens-Johnson syndrome
Toxic epidermal necrolysis
List additional medication-specific adverse effects.
Hepatotoxicity
Nevirapine
CNS toxicity and vivid or disturbing dreams: efavirenz
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