List GI symptoms.
Gastrointestinal symptoms are common in children. The presence of these features during infancy should raise suspicion for CF.
Meconium ileus (in newborns)
Failure to thrive (due to malabsorption)
Exocrine pancreatic insufficiency
Foul-smelling steatorrhea (fatty stools) may occur.
Deficiency of fat-soluble vitamins
CF-related diabetes mellitus (CFRD)
Liver and bile duct abnormalities
Fatty metamorphosis of the liver, eventually progressing to liver cirrhosis
Biliary cirrhosis with portal hypertension, jaundice, and/or esophageal varices
Intestinal obstruction: abdominal distention, pain, and a palpable mass
Rectal prolapse (rare)
In almost all cases of meconium ileus, cystic fibrosis is the underlying disease.
Describe respiratory symptoms.
Respiratory symptoms are common in adulthood. CF should be considered in individuals with the following features:
Chronic obstructive lung disease with bronchiectasis
Chronic sinusitis: nasal polyps may eventually develop
Recurrent or chronic productive cough and pulmonary infections
S. aureus is the most common cause of recurrent pulmonary infection in infancy and childhood.
P. aeruginosa is the most common cause of recurrent pulmonary infections in adulthood.
Other commonly involved bacteria
Burkholderia cepacia: can lead to cepacia syndrome, a severe necrotizing pneumonia that is often accompanied by rapid respiratory decline and can progress to sepsis 
Increased susceptibility of individuals with CF to opportunistic, potentially life-threatening pathogens (e.g., Pseudomonas aeruginosa, Aspergillus)
Infections with Pseudomonas aeruginosa → rapid decline in pulmonary function (patients with CF go through multiple antibiotic courses in their lifetime → increasing resistance of Pseudomonas aeruginosa to commonly used antibiotics) 
A chronic infection with Aspergillus species may lead to allergic bronchopulmonary aspergillosis (see “Complications” below)
Pulmonary obstruction and airway hyperreactivity may manifest with expiratory wheezing and/or dyspnea.
Barrel chest , moist rales (indicate pneumonia), hyperresonance to percussion
Signs of chronic respiratory insufficiency: digital clubbing associated with chronic hypoxia
List urogenital symptoms.
Frequent urinary tract infections
Men: usually infertile
Obstructive azoospermia is common, spermatogenesis may be intact
The vas deferens may be absent.
Women: reduced fertility
Viscous cervical mucus can obstruct fertilization.
Menstrual abnormalities (e.g., amenorrhea)
Delayed development of secondary sexual characteristics