Describe general principles.
Increased severity or new onset of clinical symptoms can be a sign of acute pulmonary exacerbation.
There are no universally accepted diagnostic criteria.
Findings are varied and include increased dyspnea or cough, changes in sputum production, weight loss, and fever
Start culture-guided antibiotic therapy for pulmonary exacerbations.
Treat pulmonary exacerbations quickly and aggressively to prevent an irreversible decline in lung function.