Clinical Features

A diarrheal illness (usually bloody) for the past 5–10 days precedes the onset of HUS symptoms in many children.

• Thrombocytopenia

  • Petechiae, purpura

  • Mucosal bleeding

  • Prolonged bleeding after minor cuts

• Microangiopathic hemolytic anemia

  • Fatigue, dyspnea, and pallor

  • Jaundice

• Impaired renal function

  • Hematuria, proteinuria

  • Oliguria, anuria

The typical HUS patient is a preschooler who has had a diarrheal illness for the past 5–10 days and presents with petechiae, jaundice, and oliguria.