Toxins

Paralysis due to blocking of Action potential

• actually caused by bacteria

there are different conotoxins

• w-conotoxin: blocks Ca2+ channels related to algesia (pain) -> analgesic effect

ungleich Tetrodotoxin

inhibition in cardiac muscle cells

=> Digitalis acts in a positive ionotropic (->stronger heart beat) and negative chronotropic (-> brachicardia) fashion

symptoms:

+prevents migration of leukocytes

Ricin has a chain (enzymatically active) and b chain (cell binding)