Describe the ulcerative/erosive disease as a cause.
Peptic ulcer disease:
Most common cause of stomach and duodenal perforation
Duodenal ulcers of the anterior wall are more likely to perforate.
Inflammatory bowel disease: ulcerative colitis, Crohn disease
Describe infections as a cause.
Diverticulitis (colonic diverticula, Meckel diverticulum)
List other causes.
Inflammatory bowel disease
Bowel obstruction (i.e., adhesions, volvulus, malignancy)
Acute mesenteric ischemia
Penetrating trauma (e.g., stab injury, iatrogenic perforations): e.g., post-ERCP duodenal perforation
Blunt abdominal trauma
Foreign body ingestion
Drug-induced (e.g., NSAIDs, glucocorticoids, cocaine)
Radiation therapy to the abdominopelvic or lower thoracic region
Post renal transplant