Loss of skin elasticity, wrinkling and thickening of skin on face region
Thickening and callus formation on limb and food pad
Dog, oral cavity
Dental calculus
Acquired oligodontia - loss of teeth
Dog, esophagus
Cystic dilation of the esophageal glands
Dog, Liver, Atrophy and fibrosis
Dog, liver
Cystic mucinous hyperplasia of the mucus-producing glands in the mucosa of the gallbladder
Pulmonary anthracosis
Incidental finding
Cat, pancreas
Nodular hyperplasia of the exocrine parenchyma
Spleen
Nodular hyperplasia (NH) and metastatic tumors – cholangiocarcinoma (CC)
Cat, kidney
Renal cysts Incidental finding
Dog, large breed stomach
Gastric dilation and volvulus
Dog, German Shepherd (large breed !!!)
Splenic hemangiosarcoma with multiple metastatic nodules in the omentum and mesentery Histologically, the blood vessels are filled with red blood cells and are lined by pleomorphic endothelial cells.
Cat, Sphinx, heart
Hypertrophic cardiomyopathy (HCM)
Young dog (2 months),PDA
Cardiomegaly due to hypertrophy of the RV
Old dog, kidneys
Bilateral atrophy
Male dog, prostate gland adenocarcinoma with pulmonary metastases
Dog, female
Mammary gland adenocarcinoma
Dissemination of the neoplastic cells via lymphatic vessels (histo picture!)
Pulmonary metastases
Dog, heart, left side
Subvalvular aortic (subaortic) stenosis A
fibrous band is present beneath the aortic valve (arrow)
Sudden death!
Dog
Laryngeal and pharyngeal hemorrhages and edema Anticoagulant poisoning
Diaphragmatic hernia
1. Dog, hemothorax, anticoagulant poisoning
Sudden death!!!
Dog, traumatic hemothorax
Dog, 1y old
Transmural gastric ulcer
Dog, 3y old
Mesenteric hernia and venous infarction
2-week-old newborn puppy
Hemorrhages in the renal cortex + cortical necrosis
Cause: systemic infection with canine herpesvirus
Neonatal death
1-week-old newborn puppy
Acute fibrinous peritonitis, hemorrhagic enteritis
Cause: bacterial infection (Salmonella spp, E. coli)
Puppy, kidneys
Unilateral hypoplasia and dysplasia
Puppy, heart
Complete transposition of arteries (grade 4)
Puppy, Bichon Frisé
Internal hydrocephalus and atrophy of the nervous tissue
Puppy, neonatal death
Traumatic hepatic rupture and hemoperitoneum
Puppy
Purulent choroiditis with accumulation of exudate in the lateral ventricles
Cytology: a large number of neutrophils and fewer macrophages Bacteriology: Pseudomonas spp. (green colonies) and E. coli infection
Cause: maternal factor - mastitis
Cytology: a large number of neutrophils and fewer macrophages
Bacteriology: Pseudomonas spp. (green colonies) and E. coli infection
Cat
Severe, acute, negative pressure
Pulmonary edema
Perianesthetic death (during general anesthesia)
Negative pressure pulmonary edema (NPPE), the noncardiogenic pulmonary edema, is caused by upper airway obstruction and rapid negative intrapleural pressure increasing due to attempts of inspiration against the obstruction. This occurs as a serious complication of general anesthesia with tracheal intubation, and more than half of these cases are related to postanesthetic laryngospasm
Severe pneumothorax
Perianesthetic death (after general anesthesia)
Aspiration pneumonia
History: Traumatic injuries due to a car accident
Postmortem: Severe, chronic, verminous pneumonia
Aelurostrongylus abstrusus
Perianesthetic death
Severe, acute, traumatic hemothorax
The lesions are caused by resuscitation
Dog, F
Death after surgery (ovariohysterectomy)
Acute, severe, hemoperitoneum
Ovarian artery hemorrhage
Dog,
Parvoviral enteritis
Severe, diffuse, acute necrotizing enteritis
Dog, 2mo
Diffuse, severe, necrotizing enteritis with intranuclear inclusion bodies (arrow)
Moderate infiltration of the lamina propria and submucosa with neutrophils, macrophages and lymphocytes
CDV (Canine Distemper virus) infection
Crusty nose
Diffuse bronchointerstitial pneumonia: the lungs are diffusely rubbery with rib imprints on the pleural surface; intracytoplasmic and intranuclear, acidophilic, viral inclusion bodies (black arrows).
Dogs
Facial skin abrasions (due to intense itching)
Pseudorabies (Aujeszky's disease)
Suid herpesvirus 1 (SuHV-1)
CAV 1 infection
Petechial hemorrhages on the intestinal serosa
Diffuse thickening (edema) of the gallbladder wall
Acute, severe necrotizing hepatitis
Intranuclear viral bodies (arrows ) Rubarth disease : CAV 1 infection
Acute leptospirosis
Jaundice, splenic congestion
Cause: Leptospira spp.
Dog, kidney
Urinary bladder hemorrhages
Hemorrhages (petechiae) in the renal cortex + cortical necrosis and jaundice
Severe pulmonary hemorrhage, edema and jaundice
Necrotizing fasciitis (toxic shock syndrome)
Cat,
Feline infectious peritonitis (FIP), effusive form
Intraperitoneal gelatinous fluid admixed with numerous white-yellow fibrin strands
Histo
necrotizing and pyogranulomatous vasculitis,
severe edema
FHV1 infection
Bilateral, purulent keratoconjunctivitis
Multifocal, ulcerative dermatitis
Cat, FHV1 infection
Acute bronchointerstitial pneumonia
Large intranuclear viral inclusion bodies
Large intranuclear viral inclusion bodies (arrows)
Feline Calicivirus (FCV) infection
Multifocal ulcerative glossitis
anticoagulant rodenticide (Brodifacoum) poisoning
White mucous membranes
diffuse haemorrhages around the spleen
pericardial haemorrhages
Diffuse pulmonary hemorrhage
haemothorax
subcutaneous haemorrhage
Acute, severe, diffuse, tubular necrosis, calcium oxalate crystals (arrows)
Cause: ethylene glycol intoxication (calcium oxalate)
Dog, autoimmune hemolytic anemia (AIHA)
Jaundice (icterus)
Jaundice (icterus), splenomegaly
Hemoglobinuria (“port wine” urine)
Peripheral blood smear (Wright’s - 100x)
Several characteristics findings of autoimmune hemolytic anemia polychromasia (blue arrows), spherocytes (black arrows), a metarubicyte (red arrow), and Howell-Jolly bodies (green arrows)
Cachexia
Dog, with progressive weight loss
Oral cavity, infiltrative melanoma
Emaciated dog
Cause: masticatory myositis
Cause: Congenital idiopathic megaesophagus (CIM)
Hypertrophic gastropathy
Diffuse form
middle : Gastric mucosal hypertrophy, LP infiltrate
right : Gastric mucosal hypertrophy. Mucous metaplasia of glands
Stomach - body region
Giant hypertrophic gastropathy
Menetrier-like disease
Dog, progressive weight loss
Lymphoplasmacytic enteritis and lymphangiectasia (arrow)
Cat, with progressive weight loss
Alimentary (intestinal) lymphoma + mesenteric lymphadenopathy (arrows)
FeLV+
Pancreatic hypoplasia/ atrophy
Pancreatic insufficiency
Pancreatic lipomatosis (fatty replacement)
Verminous pneumonia —> Aelurostrongylus abstrusus
Metastatatic mineralization
Renal failure
Chronic renal failure
FNA, bone marrow: macrophages containing amastigotes of Leshmania spp (arrow).
Bilateral hydronephrosis
......ovariohysterectomy (!)
Malignant, multicentric lymphoma
- enlargement of spleen
- enlargement of spleen & lymph nodes
Skin lymphoma
Gastric adenocarcinoma with transmural ulceration
Pulmonary adenocarcinoma
Hypertrophic osteopathy (paraneoplastic feature)
Lungs, metastatic mammary gland carcinoma
Skeletal, appendicular Osteosarcoma (OSA) + pulmonary metastases
Dog, sudden abdominal distention
Gastric volvulus, tympany and venous infarction
Mesenteric hernia, tympany & venous infarction
Rupture of splenic Hemangiosarcoma (HSA)
Hemoperitoneum
Cause: Rupture of splenic HSA
Dog, progressive abdominal distention
Ascites, chronic hepatic congestion
Cause: Congestive heart failure
Dog, progressive abdominal distention9+ ascites, chronic hepatic congestion
Dog, progressive abdominal distention + Ascites
Cause: Hepatic cirrhosis, atrophy
Ascites
Cat, progressive abdominal distention
Feline infectious peritonitis (FIP): effusive form
Serofibrinous peritonitis
Dog, abdominal distention
Acute fibrinopurulent peritonitis
Cause: intestinal perforation
Cytology:
neutrophils, macrophages, bacteria
Pyometra
Ascites, subcutaneous edema
Bile duct carcinoma (cholangiocarcinoma)
Hepatocellular carcinoma + metastases
Splenomegaly, hepatomegaly
Cause: lymphoma
Splenomegaly, histiocytic sarcoma (HS)
Unilateral, ovarian fibroma
Bilateral abdominal cryptorchidism
Unilateral, testicular Sertoli cell tumor
Dog, hemorrhagic diarrhea
Severe,acute, segmental necrotizing and hemorrhagic enteritis
Fibrin strands on the surface of intestinal serosa
Canine parvovirus type 2 (CPV2)
Necrotizing and haemorhagic enteritis
Canine coronavirus infection.
Left : Severe atrophy of intestinal villi with attenuated low cuboidal to squamous enterocytes.
Right : Coronavirus antigen is present within the cytoplasm of
infected villous enterocytes (immunohistochemistry).
Boxer, colon; hemorrhagic diarrhea
Multifocal to coalescing, severe, ulcerative colitis
Cause: E.coli (?)
Cat, colon
Idiopathic ulcerative colitis
Dog, small intestine.
Intestinal candidiasis
Candida albicans
PF: Excessive antibiotic administration
Dog, intestine
Granulomatous enteritis, histoplasmosis.
The mucosa is congested and thickened due to
granulomatous inflammation
clusters of 3- to 5-μm Histoplasma capsulatum organisms (stained black) with a central nucleoid are present in macrophages.
Grocott-Gomori’s methenamine silver stain.
Giardia spp.
Cystoisospora spp.
Dog, small intestine; digestive syndrome
Canine parvovirus type 2 (CPV2)+ cestodes
Toxocara canis
Dog, small intestine,
Hemorrhagic enteritis, hookworm : Ancylostoma caninum
Dog, cecum.
The mucosa is thickened, hyperemic, and covered by many adult Trichuris vulpis; the thicker, caudal portion of the nematode is most easily seen.
Dog, ascending aorta
Dissecting aneurysm
Hemopericardium
Cause: atrial aneurysm and rupture
Dog, thoracic cavity, heart
Venous and atrial thrombosis
heart, left side, subvalvular aortic (subaortic) stenosis
A fibrous band is present beneath the aortic valve (arrow)
Dog, 2mo old, Patent Ductus Arteriosus
Cardiomegaly
Hypertrophy of the RV
Hypertrophic Cardiomyopathy (HCM)
Dog, heart
Dilated cardiomyopathy (DCM)
Mural thrombosis in the left ventricle (arrow)
Left ventricular endocardial fibrosis
Gross specimen of a heart from an Arrhythmogenic Right Ventricular Cardiomyopathy affected Boxer, demonstrating right ventricular enlargment
Histo of an enlarged right ventricle of an Arrhythmogenic Right Ventricular Cardiomyopathy boxer, showing fibrofatty replacement of cardiac myocytes.
Heart, left AV valve, myxomatous valvular degeneration “Endocardiosis”
Heart, left AV valve, myxomatous valvular degeneration
“Endocardiosis”
Heart, coronary arteries
Atherosclerosis and mineralization
Heart, multifocal subendocardial mineralization
Parvoviral necrotizing myocarditis
CPV2 infection
Intranuclear inclusion bodies (arrow)
Myocarditis and HCM in a cat infected with FIV
histo:
multifocal to coalescing areas of infiltration of the myocardium, consisting mainly of lymphocytes and, to a lesser extent, macrophages, neutrophils and plasma cells.
Focal myocarditis in a 5-year-old cat diagnosed with non effusive FIP
Coalescing granulomas distributed throughout the myocardium
Pyogranulmatous myocarditis
Bartonella henselae
Cat, heart
Pyogranulomatous myocarditis.
Macrophages with a rare multinucleated giant cells (arrow) particularly numerous at the upper left
Insert on the bottom: short bacilli in a inflammatory focus immunoreactive for Bartonella henselae-specific monoclonal antibody
Border Collie dog, heart
Multifocal necrotizing & pyogranulomatos myocarditis
(fungal infection with Scedosporium prolificans.
Intralesional fungal hyphae (Scedosporium prolificans).
Multifocal necrotizing and LH myocarditis
Trypanosoma cruzi
Intracellular pseudocysts with amastigotes
GS dog, heart
Bacterial valvular endocarditis and myocardial infarcts
Fibrinopurulent pericarditis
Streptoccocus spp.
Parasitic endocarditis
E: Dirofilaria immitis
Heart, right atrium
Hemangiosarcoma
histo :
Irregular blood channels lined by neoplastic endothelial cells
Chemodectoma (heart base tumor)
Histo:
The tumor is composed of round to polygonal cells, arranged in packets and separated by a fine fibrovascular stroma.
Neoplastic cells are mildly pleomorphic with abundant finely granular cytoplasm.
Heart, metastatic lymphoma
Nodular form
Neoplastic lymphoid cells
Heart, RV, myxosarcoma
Histo: the tumor is composed of abundant pale eosinophilic, myxoid matrix and small numbers of spindle, elongated or stellate cells
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