Nucleophilic substitution
Diels-Alder
Synthese von Prostagladin E2
Catalytic enantioselective hydrogenation
Catalytic enantioselective epoxidation
Catalytic enantioselective aldol condensation
L-Prolin als Kat für Aldol Reaktion
Chiral imidazolidinone Kat für Diels-Alder
S-Prolin as catalyst
Reaction:
Pro:
Non-toxic
Safe low cost
high enantioselectivities for aldol reactions
Contra:
reaction conditions (temp, solvent, conc reactants) is important
Mechanism of above reaction:
Mannich reactions
Mechanism:
Electrophilic interaction: (R)
Steric interaction: (S)
Imminium catalysis
Cycloaddition reactions: Diels Alder
Kat:
Synthesis of
Imminium intermediate:
Cycloaddition: Diels ALder
Epoxidations
Hydrogen Bond catalysis
Cinochona alkaloid catalysis
Ugi reaction:
Strecker und Biginelli reaction
Passerini reaction
Heck reaction
Solid phase extraction
examples of different resins
SPPS Batch vs continuous flow methos
Mix couple AS in solution: every possible sequence
-> activating reagents to form correct bond
->protecting groups to block formation of incorrect bonds
coupling methods
solid phase oligonucleotide synthesis
Last changeda year ago
