Gedachtnisprotokoll WS16-17

Early Development

A) name and describe briefly an early mechanism to establish cell polarity

B) give an example for a localized determinant and describe the mechanism, name other mechanisms for localized determinants

RTK

- what are RTKs? Explain the downstream signaling pathway

- give a short description from (proto) oncogenes and tumor suppressor genes

- are RTKs oncogenes or tumor suppressor genes, justify your answer

HOX genes

- what is the function of HOX gens

- explain the strongly expression regulation of HOX genes

Steroidhormones

- Cortisol bind to glucocorticoid receptors (GR); explain the mechanism after the binding and name the cellular localization of each step

Cell-junctions

- name 4 junctions in the epidermal layer (apical to basal)

- name for each the transmembrane protein for cell contact

- which one of the 4 have contact to cytoskeleton and name the filaments

Stem Cell

- explain the concept of the stem cell niche and name the main components of this niche

- give the important regulatory interactions there

Proteins

- what is the functional signal sequence of proteins

- name two independent cases where the signal will not be removed