Are DNA motifs part of the DNA methylation, and if yes, how can the help ?
Yes they are
help undderstand locus-specificity of DNA methylation
What is BUSCO?
quality assessment analysis
evaluate the completeness of the genome assemblies
comparing against highly conserved genes
what are transposable elements?
jumping genes: can move around in the genome
2 classes:
retropransposons
DNA transprosons
10 things of transposable elements
different forms and shapes
not randomly distributed
Source of mutations
Genome rearrangement
Expression vs repression
Affect germline and soma
not just transposision (immune response)
Creates genes and RNAs
Modifies regulatory networks
Requires specialized tools
key trends in miRna tool development
incorporation of NGS data
improvements of lab and computational techniques
Classical and novel machine learning methods
More human oriented research
Growing focus on miRNA-disease annotations
Manual curation and text mining
Maintenance and update of early tools
what is wobble ?
third position of Codon:
U/C always the same
A/G often the same
what about codon bias?
64 different codons but 20
-> some codon combinations are prefered
tRNAs carry amino acids
-> tRNAs that are more abundant are more likely
Last changed5 months ago