What is connectomics
Connectomics is the production and study of connectomes, which are comprehensive maps of connections within an organism's nervous system.
How does a axon know how /where to grow?
Axons are attracted/repelled by a other molecule
Why does a baby has a lot of activity in the cortex although does not have mature organs?
spontanious activity by neuro circuits
What do calcium pulses mean (retinol waves in still blind baby mice)?
spontaneous active neurons
How does activity influence connectivity and vice versa?
What are Homeostatic mechanisms?
preserving connections
Nomenclature long term mechanisms of placicity
Activity only knows the pre and post neuron
What is Hebb’s postulate?
‘Out of sync, out of link’
First experimental work in hippocampus: Plasticity induced by firing rate. What was the result of different frequencies of the firering stimulation?
black: stimulated, white: unstimulated
Plasticity in a feedforward network. What are we interested in?
Change in the weights
What influences the Hebbian plasticity?
Hebbian plasticity, the connections of the pre and post synapse, can modify the weights based on the correlation/covariance on the inputs
-> Covariance rule (is unstable)
What are Normalization Constraints? What types are there?
Regularization for weights. Substractive and divisive
Does the plasticity rule change?
Based on the environment
Spike-timing dependent plastiity (STDP) experiment
fireing is the same, timing is different rechts: depression
Multiple factors play a role– we focus on relative timing
Various experimental results for plasticity rules
curves look different, different in brain region and cell types
Bi and Poo rule
What is connectomics?
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