Buffl

histo-epithelial tissue

ds
von dawn S.

???

- Sheetlike extracellular structure

- Visible only with ______ microscope (20-100 nm thick)

- Consists of a delicate network of fine fibrils – ______

- Electrolucent layers on both sides – lamina ______ or lamina ______

- Composed of type ______collagen, ______ and ______


• Type ____ collagen: Monomers of type ….. collagen self-

assembled into a two-dimensional network of evenly

spaced subunits

• ____: large glycoproteins that attach to

transmembrane proteins called integrins at the cells’

basal surface and project through the network of type IV

collagen

• ____ and ____: Respectively a short, rod-like

protein and a proteoglycan, both of these cross-link

laminins to the collagen network and help determine the

porosity of the basal lamina and the size of molecules

able to filter through it.

BASAL LAMINA

- Sheetlike extracellular structure

- Visible only with electron microscope (20-100 nm thick)

- Consists of a delicate network of fine fibrils – lamina densa

- Electrolucent layers on both sides – lamina rarae or lamina lucida

- Composed of type IV collagen, laminin and proteoglycan

(heparan sulfate)


• Type IV collagen: Monomers of type IV collagen self-

assembled into a two-dimensional network of evenly

spaced subunits

• Laminin: large glycoproteins that attach to

transmembrane proteins called integrins at the cells’

basal surface and project through the network of type IV

collagen

• Nidogen and Perlecan: Respectively a short, rod-like

protein and a proteoglycan, both of these cross-link

laminins to the collagen network and help determine the

porosity of the basal lamina and the size of molecules

able to filter through it.

Author

dawn S.

Informationen

Zuletzt geändert