Which tumors cause a Humoral hypercalcemia of malignancy (pseudohyperparathyroidism): PTHrP secretion by the tumor?
Squamous cell carcinomas (lung, head, and neck)
Renal cancer
Bladder cancer
Breast cancer
Ovarian cancer
Which tumors cause an ectopic vitamin D production due to 1α-hydroxylase activity in tumor cells?
Hodgkin lymphoma
NHL
Which tumors cause a local osteolytic hypercalcemia: osteolytic activity at sites of skeletal metastases?
Multiple myeloma
List characteristic features of hypercalcemia of malignancy.
Nephrolithiasis, nephrocalcinosis
Bone pain, arthralgias, myalgias
Constipation, abdominal pain
Nausea, vomiting, anorexia
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