Name the category.
Cytotoxic agents
Name the main drug.
Vincristine
Name the subgroup where vincristine belongs to.
Mitotic inhibitor —> Vinca alkaloids
Describe the mechanism of action of vincristine.
Binding of β-tubulin → inhibition of β-tubulin polymerization into microtubules→ prevention of mitotic spindle formation → mitotic arrest of the cell in metaphase (M-phase)
List indications.
Solid tumors
Neuroblastoma
Rhabdomyosarcoma
Nephroblastoma
Other
Acute lymphocytic leukemia
Hodgkin lymphoma
NHL
List adverse effects.
Neurotoxicity (e.g., areflexia, peripheral neuropathy)
Paralytic ileus, constipation
Extravasation can cause significant irritation and/or ulceration of local tissue
Acute bronchospasm
Uric acid nephropathy
Zuletzt geändertvor 2 Jahren