Name the category.
Immunomodulator agents
Name the main drug.
Ciclosporin
What is the group of cylcosporin A?
Calcineurin inhibitors (calcineurin = calcium- and calmodulin-dependent serine-threonine phosphatase)
Describe the mechanism of action of cyclosporine A.
Immunosuppression: binding of cyclophilin → inhibition of calcineurin → inhibition of NFAT activation → ↓ IL-2 transcription → ↓ activation of T cells
Cytostatic action: binding to multidrug resistance glycoprotein P-170
Is the cell mediated or humoral response supressed by cyclosporine A?
cell-mediated
List indications of cyclosporine A.
Transplant rejection prophylaxis (in combination with other immunosuppressants)
Psoriasis
Rheumatoid arthritis
List side effects of cyclosporine.
Gingival hyperplasia
Hypertrichosis and hirsutism
Nephrotoxic, neurotoxic
Diabetogenic effects
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