Alpha-adenoceptor antagonists

Doxazosin

Antihypertensive therapy

Alpha-1 receptor antagonists

• Benign prostatic hyperplasia

• Arterial hypertension

• Orthostatic hypotension

• Retrograde ejaculation

• Dizziness, headache

• Peripheral edema, hypotension

• Nausea, constipation

• Intraoperative floppy iris syndrome (IFIS)

  • Complication of cataract surgery characterized by iris prolapse through the surgical incision and intraoperative pupillary constriction

  • May lead to retinal detachment and endophthalmitis

• Urinary frequency

• Prazosin: priapism

• Reduces peripheral vascular resistance and BP as a result of vasodilating effects; produces both arterial and venous dilation. 

• Binds to α-adrenergic receptors on the prostate capsule, prostate adenoma, and the bladder trigone, resulting in decreased urinary outflow resistance in men.

• May improve to limited extent the serum lipid profile (e.g., small increases in HDL and HDL/total cholesterol ratio; small decreases in LDL, total cholesterol, and triglyceride concentrations). Can decrease blood glucose and serum insulin concentrations.