• the imbalance of lipids such as cholesterol

• disorder of lipid and lipidproteinmetabolism

• imbalance of LDL-C (low-density lipoprotein cholesterol), tryglycerides, and HDL (high-desity lipoprotein)

  
  

• Elevated triglycerides

• Elevated LDL

• Elevated cholesterol

• Reduced HDL

Organic Molecules that are soluble in organic solvents but not water

Contain fatty acids or their derivates

Neutral Lipids:

• Triglycerides

• Diglycerides

• Monoglycerides

• Free Fatty Acidds

Phospolipids

• Cholines

• Ethanolamines

• Serines

Sterols

• Cholesterols

• Cholesterols Esters

Waxes

• Ceramides

• VLC

Organic Molecules that are soluble in organic solvents but not water

Contain fatty acids or their derivates

Neutral Lipids:

• Triglycerides

• Diglycerides

• Monoglycerides

• Free Fatty Acidds

Phospolipids

• Cholines

• Ethanolamines

• Serines

Sterols

• Cholesterols

• Cholesterols Esters

Waxes

• Ceramides

• VLC

Transfats disrupt normal membrane structure & cause aggregation of lipis, formin plaques or blockades over time the veins

Transfats are more thermodynamic stable in higher trempreture

omega 3 acids have from the end counting on th C3 position a unsteady bond

• can not be synthesised by humans

• necessary for the growth and human brain function

• anti-inflammatory properties

• 1 g/ day needed

• main compound of stored human body fat

• tree fatty acids and glycerol

Two major enzyme classes control TG level:

• Lipadases -> degradation

• Diaclglycerol acetyltransferades -> sytehesis

Testings:

<150 mg/dL

< 1.70 mmol/L

• 30% of the human membrane

• maintains membran fluidity & itrity in different tempretures

• 50% diet 50 % synthesised

• <5.2 mmol/l low risk

• 6.2 high risk

  
  

Biochemical assembly of lipids and proteins for efficient transporting fats in the body

Transport occurs trough the lympatic & circulatory system

Lipids: phospholipids, triglycerides & cholesterols formin membranes

Proteins: Apoproteins are embedded in these membranes

Apolipoproteins stabilize and determine

• Apo-Lipis are detergents to pack lipids and to solubilise for transport

• apo-lP have different receptor ligands, and different tissues

• Indicator for health issues

VLDL>IDL>LDL>HDL

dencity decreasing & volume increasing

VLDL- 50% triglycerides & cholesterols, 30% cholesterol content

LDL - 65 % cholesterol (20% less volume than VLDL)

Hdl (high protein) good fat

• Major Phospholipids + Cholesterol Depot

Early:

• diet control, sports, weight controll

• Omega 3 and niancin supplementation

Indikactor: HIGH LDL- cholesterol

1. bile acid binders

   • change cholersterol into cholic acid

2. Cholesterol absorption inhibitors

   • Decreases cholesterol absorption in the intestine

   • increasing of cholesterol extraction

Indicator: High VLDL-cholesterol, high TG

Drug: Strains (atorovastin, flucvastin) most common method

• Blocks cholesterol biosynthesises

• increasing removal of cholesterols from the body

• blocking HMG-Coa reductase