How does Hyperglycemia induces tissue damage?
repeated acute changes in cellulare metabolism
long term changes in stable macromolecules
The two main comlications from Diabetes?
Macrovascular: accelerated atherosclerosis (closing of artery)
Microvascular: retinopathy, neuropathy, nephrophaty (capilary system)
Wich cells are susceptible?
Retinopathy: capillary endothelial cells in the retina
Neuropathy: Schwann cells in peripheral nerves
Nephropathy: Mesanglial cells in the renal
How is diabetes effecting retinopathy?
Because of the diabetis a hyperglycemia is glycolysining glycoproteins
Diabetic Neuropathy?
Diabetic Peripheral Neuropathy
Polyol Pathway
NADPH is consumed stoichiometric to glucose by aldol reductase
NADPH is essential to regenerate the intracellular antioxidant, glutathione
Hence polyol pathway increases the susceptibility to intracellular oxidative stress (increases ROS)
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