Describe the overall diagnostic approach.
Screening for lipid disorders
Indications
All individuals 40–75 years of age [12][13]
Patients with a family history of familial hypercholesterolemia or premature ASCVD: Consider earlier screening.
Tests
Adequate in most cases: nonfasting lipid profiles
Nonfasting triglycerides > 400 mg/dL or if evaluating for familial lipid disorders: fasting lipid profile
Assess ASCVD risk to guide treatment decisions, e.g., via the 2013 ACC/AHA pooled cohort equation
Lipid profile.
Describe the assessment for secondary causes of hyperlipedemia.
Adults 20–39 years of age with hyperlipidemia
Consider in adults of any age with LDL > 190 mg/dL
Tests include:
Fasting blood glucose or HbA1c
TSH
Liver function tests
Urine analysis and serum creatinine
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