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Describe the pathophysiology (detailed).
Cholera toxin activates the Gs α subunit, thereby stimulating adenylate cyclase activity to increase cAMP within the intestinal epithelial cells. Increased cAMP concentration overactivates cytosolic PKA, which phosphorylates CFTR chloride channel proteins, causing excess secretion of Cl- (and subsequently water, Na+, K+, and HCO3-). This process leads to watery, greyish stools and severe dehydration, as seen in this patient.
Zuletzt geändertvor 2 Jahren