Define renal cortical necrosis.
rare cause of AKI caused by acute generalized ischemic necrosis of the renal cortex in both kidneys
Describe the causes as well as the pathophyisology.
Etiology: septic shock, disseminated intravascular coagulation (DIC), hemolytic uremic syndrome (HUS), obstetric complications (e.g., abruptio placentae, septic abortion, postpartum hemorrhage)
Pathophysiology: vasospasms and microvascular injury with vascular thrombosis → prolonged severe renal ischemia → diffuse and/or patchy destruction of the renal cortex
List clinical features and describe the management and prognosis.
Clinical features: flank pain, CVA tenderness and signs of AKI (see also “Clinical features” above and shock)
Management: Dialysis can improve outcomes (see “Management” below).
Prognosis: high mortality rates without treatment
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