Define mononeuritis multiplex.
a group of disorders characterized by ≥ 2 isolated mononeuropathies; e.g., concurrent sciatic neuropathy and radial neuropathy
List causes.
Axonal injury caused by damage to vasa nervorum
Occurs in conditions characterized by the development of granulomas and/or microangiopathy (e.g., diabetes mellitus, rheumatoid arthritis, vasculitides, SLE, Lyme disease, amyloidosis, HIV, polyarteritis nodosa)
What are clinical features?
painful, asymmetrical sensory and motor symptoms
List diagnostics.
Confirm with electrodiagnostic testing and test for possible etiology.
What is the treatment?
analgesia (see “Pain management”) and treatment of the underlying condition
List other considerations.
Radicular neuropathy: associated with acute onset of severe back pain that radiates to the legs and arms
Amyotrophic lateral sclerosis: asymmetrical limb weakness with fasciculations and muscle stiffness
Peripheral vascular disease: trophic skin changes and pain exacerbated by walking
DDs.
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