Liver immunity
Liver architecture
Liver cells
LSECs
no basement membrane
sieve plates (T cells can reach through fenestrations)
immune sentinels and antigen presenting cells
important for immune tolerance and surveillance
pattern recognition
antigen presentation
leukocyte recruitment
play a role in chronic inflammation
Kupffer cells
intravascular liver macrophages
derived from monocytes
play a role in chronic liver disease (e.g. primary sclerosing cholangitis, NASH = Nonalcoholic steatohepatitis)
interact with platelets —> anti-platelet therapy reduces liver damage and tumor development
Kupffer cells in infection
catch bacteria
kill them with ROS
Tacrolimus and the liver
Tacrolimus
immunosuppressive
inhibits IL-2 production
stops development/proliferation of T cells
Tacrolimus and Kupffer cells
reduces bacterial capture
decreased ROS production after infection
Zuletzt geändertvor 2 Jahren
