Central dogma od biology
What is a target?
How many targets are roughly drugged in bacteria and humans?
Explain the levels and steps of genome sequencing projects (diagram)
Describe the basic principles of chain termination sequencing.
Mention two high throughput sequencing techniques.
How many genes of unknown function can be expected in a bacterial genome?
What are essential genes, how many can be expected in bacteria and how can these be analyzed?
How is an DNA microarray constructed?
Describe the steps of a standard DNA microarray experiment.
What are the initial steps for RNA-Seq?
Describe the terms “proteome” and “proteomics”
What are main problems of protein chemistry in respect to proteome analysis?
Describe the basic steps of protein analysis via 2-D PAGE and MALDI-ToF-MS.
Which groups of proteins cannot be analyzed by 2-D PAGE?
How many proteins and their variants can be estimated from the human genome?
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