What does cell polarity mean?
asymmetric organization of cell structures, functions and shape
Often implicated from extracellular signal which bind to receptors of the cell
what role does polarity plays for different processes?
asymmetric cell division (e.g. stem cells, progenitor cells)
Epithelial polarity (aprico-basal cell polarity-> one side facing the outside and one in contact with Baal extracellular matrix)
Cell migration
Immunological Synapse (e.g. short distance communication)
Neural polarity (e.g. long range communication)
Why is cell polarity important for asymmetric cell division?
How does it happen?
produces two daughter cells with different cellular fates
Stem cells divide asymmetrical-> one cell stays stem cell and one cell differentiates
Extrinsic signal
induced by surrounding cells or precursor cells
Intrinsic signal
Asymmetric protein localization within the cell
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