v gated sodium channels depolarization
v gated chloride channels hyperpolarization
v gated potassium channels only to antiepileptic drugs
gi go coupled gpcrs
calcium v gated channels (n and pq type)
potassium v gated channels
local anesthetics only at v gated sodium channels
mood stablizers and anti epileptic drugs (both) - only at v gated calcium and chloride channels
excitatory ligand gated ion channels
glutamate
nicotinic cholinergic
serotonin 5ht
inhibitory ligand gated ion channels
gaba
glycine
glutamate r
glutamate major excitatory nt
nmda r (ligand gated sodium and calcium channels)
ampa (mostly ligand gated sodium, bit calcium)
nmda blocked by phencyclidine, ketamine
involved memory, learning
also has metobotropic receptors (as ligand gated ion channel) - intermediate step like GPCR
nmda receptor
ligand gated sodium and calcium channels, excitatory glutamate receptor
ampa receptor
ligand gated sodium channel mostly, bit calcium, excitatory glutamate receptor
nmda blocked by
phencyclidine, ketamine
glutamate r involved in
memory, learning
nicotinic cholingergic channel
excitatory, ligand gated ion channel
permeable to sodium in periphery
perimeable to sodium and calcium in cns
permeable to sodium
most are gpcr (as ligand gated excitatory ion channel)
blocked by ondansetron
serotonin 5ht blocked by
ondansetron
serotonin 5ht permeable to
only sodium
excitatory ligand gated ion channel, and gpcr
serotonin 5ht (most are GPCR)
glutamate (metabotrophic receptors mostly, intermediate step like GPCR)
inhibitory ligand gated ion channels ion acton
gaba and glycine increase intracellular chloride
majory inhibitory transmitter, other one
gaba major
gaba drugs
anticonvulsants
barbiturates
benzodiazepines
convulsant
inhalant and iv anesthetics
gaba what extra receptors
also has metabotrophic receptors
GABA B intermediate step like GPCR
glycine what drug
blocked by strychnine
strychine
blocks glycine receptor
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