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Early Development
A) name and describe briefly an early mechanism to establish cell polarity
B) give an example for a localized determinant and describe the mechanism, name other mechanisms for localized determinants
RTK
- what are RTKs? Explain the downstream signaling pathway
- give a short description from (proto) oncogenes and tumor suppressor genes
- are RTKs oncogenes or tumor suppressor genes, justify your answer
HOX genes
- what is the function of HOX gens
- explain the strongly expression regulation of HOX genes
Steroidhormones
- Cortisol bind to glucocorticoid receptors (GR); explain the mechanism after the binding and name the cellular localization of each step
Cell-junctions
- name 4 junctions in the epidermal layer (apical to basal)
- name for each the transmembrane protein for cell contact
- which one of the 4 have contact to cytoskeleton and name the filaments
Stem Cell
- explain the concept of the stem cell niche and name the main components of this niche
- give the important regulatory interactions there
Proteins
- what is the functional signal sequence of proteins
- name two independent cases where the signal will not be removed
ER retention Signal
Transmembrane Proteins
Nuckelt import / Export Signal (Mechanismus with Phospho and inhibitory protein)
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