Explain possible chemical routes (4) to afford a decarboxylation of metabolites?
Compare thiamin diphosphate-dependent and PLP-dependent decarboxylases! Name commonalities and differences in the mechanisms! Describe how PLP enzymes control reaction specificity by stereoelectronic control!
Explain the mechanism of pyruvoyl-dependent decarboxylations!
Which reaction is catalyzed by acetoacetate decarboxylase? Draw the mechanism and explain the different functional roles of the two neighboring lysine residues!
Explain the catalytic strategy employed by mevalonate pyrophosphate decarboxylase!
Name different suggested mechanisms for oritidine-5’-monophosphate decarboxylase! Which one(s) are supported or rules out by the experimental results?
Explain the mechanism of pyruvate formate lyase (PFL) and of the required PFL activase!
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