Virologie

Susceptibility: The cell expresses a receptor for viral entry. Thevirus can enter the cell.

Permissivity: The cell can multiply the virus and release new viruses

envelope: viral membrane

Envelope protein: viral protein embedded into viral membrane

capsid: viral protein corenucleocapsid: capsid that directly interacts with the viral genome

pfu: plaque forming units

moi: multiplicity of infection

CPE: cytopathic effect

+ssRNA, -ssRNA, dsRNA, +ssDNA, -ssDNA, dsDNA: positive- or negative-oriented single stranded or double stranded RNA/DNA

ID50: infectious dose that infectes 50%

CCID50: ID50 in cell culture (cell culture infectious dose 50%)

LD50: lethal dose 50%; dose at which 50% of animals die

budding: release of viral paticles through a cellular membrane andthe acquisition of a vial envelope through this process

Virus-like particle: empty capsids that spontanously form fromcapsid monomers; used for vaccines

in vitro: - experiments with enzyme mix (e.g. in an Eppi),

- experiments in cell culture

in vivo: - experiments in living organisms

- examples: animal experiments, treatment of patients

tropism: which cell type can become infected?

host range (Wirtsspektrum): which species can become infected?

RBD: receptor binding domain

FP: fusion peptide

Viral aaachment: lose binding to aaachment factors

Viral binding: binding to entry receptor

Affinity: strength of binding between ligand and receptor

Avidity: sum of all affinities if multiple binding sites exist