what is mRNA surveillance?
mRNA surveillance is the cell’s quality-control system for messenger RNAs. It detects defective or improperly processed mRNAs and routes them to degradation so they do not produce harmful proteins.
A: Exported mRNA is checked
B: Translation
C: mRNA is sent for celanup
nonsense-mediated decay for premature stop codons
no-go decay for ribosome stallin
non-stop decay for missing stop codons.[oup +1]
what are the main surveillance steps?
Storage
degradation
stress-related sequestration
what happens to granules under stress?
forms granules and p-bodies
how are stress granules activated?
how are stress granules composed?
Predominantly comprise proteins and RNA ssociated with translation initiation
Translation initiation complex
RNA-bidning proteins
nuclear shuttling proteins
involved in SG-PB action
epigentic factors
how are p bodies composed?
Comprise proteins associated with mRNA degredation
decapping and deadnylase enzyme complex
epigenetic factor
translation initiation complex
what is the function of Stress granukes?
fine tuning of the proteome in response to stress by selective sequestration (GAPDH, IGF2, ß-actin) or exclusion (HSP70, HSP90) of mRNAS
What is the function of p(rocessing) bodies?
storage of translationally repressed mRNAs in SGs and PBs until favorable condirions return
In which diseases are SGs and PBs involved?
Neurodegenerative diseases
Cancer
Viral infection
Inflammatory diseases
Ischemia
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