What are IPOD, CytoQ and the other sequestration compartment mentioned in the lecture?
IPOD (insoluble protein deposit)
CytoQ (cytoplasmic quality-control compartment)
JUNQ/INQ as other quality-control sequestration compartments
What are the differences between these compartments?
JUNQ/INQ are associated with more dynamic and often ubiquitinated substrates,
IPOD contains more insoluble/amyloid-like aggregates,
CytoQ is a cytoplasmic holding compartment for misfolded proteins
Where are the different sequestration compartments localized?
JUNQ is juxtanuclear
INQ is intranuclear,
IPOD is typically perivacuolar
CytoQ is located in the cytoplasm.
What are their functions?
They reduce cytotoxicity, prevent exhaustion of protein quality-control machinery, support later refolding, and facilitate routing to UPS or autophagy
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