What are stress granules?
Stress granules are cytoplasmic mRNP condensates that contain stalled translation initiation complexes formed under stress.
What are P-bodies?
P-bodies are cytoplasmic granules enriched in factors involved in mRNA repression and decay.
Under which conditions are stress granules and P-bodies formed?
They form under stress conditions such as heat, oxidative stress, UV irradiation, amino acid starvation, viral infection, and ER stress that inhibit translation initiation
What are the functions of stress granules and P-bodies?
Stress granules are involved in mRNA triage/storage during stress, whereas P-bodies are involved in mRNA repression and degradation
Which types of proteins/components are found in them?
mRNAs
RNA-binding proteins
translation factors
decapping/decay enzymes
helicases
other stress-associated proteins
Which compartment is associated with mRNA degradation and which with mRNA storage?
P-bodies are mainly associated with mRNA degradation
stress granules are mainly associated with mRNA storage/triage.
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