How is a peptide bond formed?
Condensation reaction between two amino acids:
N-terminal OH from carboxyl-group & C-terminal proton from Amino-group
This reaction does not occur spontaneously in aqueous solution
must be carried out in ordered fashion (NH2-Ala-Gly is different than NH2-Gly-Ala)
order of aa should be template dependent (mRNA)
Efficiency of the reaction should be independent of amino acid type
otherwise some proteins may be synthesized preferably
What are the properties of a peptide bond?
Peptide bonds are covalent links between amino acids, formed by condensation between the carboxyl group of one and the amino group of another.
They exhibit partial double-bond character (due to resonance), making them planar and rigid, limiting rotation and stabilizing protein structure
Please draw the chemical structure of the predominant form of the linear pentapeptide HDRYV at pH 2,5 in aqueous solution.
Draw the peptide HKEFI in aqueous solution with pH 2.5.
Draw Histidine by pH 6.5. Which of these forms is a strong base and which is an acid?
Draw the peptide MTCE at pH7
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